Product details
Adequan® Canine is recommended for intramuscular injection for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints. This is more commonly known as osteoarthritis (OA).
- Adequan® Canine (polysulfated glycosaminoglycan) is the only FDA-approved disease-modifying osteoarthritis drug for dogs.
- It proactively treats the disease and not just the signs.
- Adequan® Canine helps to restore joint lubrication, relieve inflammation, and renew the building blocks of healthy joint cartilage - to help keep dogs moving.
- Adequan® Canine can be used early, at the first clinical signs of degenerative joint disease (DJD).
- Continue to use it as prescribed by your veterinarian to treat arthritis and help maintain mobility and comfort.
Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.
For
Dogs
Active ingredient(s)
Polysulfated glycosaminoglycan (PSGAG)
Inactive ingredients
Benzyl alcohol (preservative), water for injection. May contain sodium hydroxide and/or hydrochloric acid if necessary to adjust pH.
Brand name
Adequan Canine
Drug class
Disease-modifying osteoarthritis drug (DMOAD)
Manufacturer
American Regent Animal Health
Product strength & size
This sterile injectable solution contains 100 mg of polysulfated glycosaminoglycan per 1 mL of solution and is supplied in 5 mL preserved multiple dose vials. Please ensure the selected product and package size are appropriate for your pet, as recommended by your veterinarian.
For current availability, please refer to the product selection above.
Usage
*For complete product information, please review the Full Prescribing Information in the manufacturer’s package insert.
Adequan Canine should be administered as directed by your veterinarian. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.
Manufacturer’s Recommended Dosage and Administration:
The recommended dose of Adequan Canine is 2 mg/lb. body weight (0.02 mL/lb., or 1mL per 50lb), by intramuscular injection only, twice weekly for up to 4 weeks (maximum of 8 injections).
Please consult with your veterinarian and follow all treatments as prescribed. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Injectable medications require needles, syringes, and a designated sharps disposal container. These are not included with the medication and must be purchased separately.
Please consult your veterinarian for guidance regarding appropriate needle and syringe sizes for your pet.
For general injectable use (aseptic technique):
Aseptic technique refers to a set of practices designed to minimize the risk of contamination and infection during medical procedures. These practices can also be applied to the handling and administration of injectable medications to your pet to help reduce the risk of post-injection bacterial infections.
Wash your hands thoroughly with soap and water before and after administration.
Use a new, sterile needle and syringe for each injection. Needles and syringes should never be reused.
Do not touch the needle, syringe tip, or vial stopper (once it has been wiped with alcohol) to any surface to avoid contamination.
Adequately clean and disinfect the vial stopper with an alcohol wipe, then allow it to dry before inserting the sterile needle/syringe.
Withdraw and administer the prescribed dose as directed by your veterinarian.
Dispose of the needle/syringe into a proper sharps disposal container immediately after use.
Missed doses
If a dose is missed: Please consult your veterinarian.
If you have questions about your pet’s prescribed dosing schedule (e.g., timing, interval), please consult your veterinarian.
Storage
Adequan® Canine does not need to be refrigerated.
Store at 68° to 77°F, excursions permitted to 59° to 86°F. Avoid prolonged exposure to temperatures ≥ 104°F. Use vial within 28 days of first puncture and puncture a maximum of 10 times.
Keep in a secure location out of the reach of children and pets. Exposure to extreme temperatures or moisture may affect the integrity and effectiveness of medications. Always store medications properly (e.g., away from the bathroom, kitchen sink, or other damp places).
Side effects
Side effects in clinical studies (transient pain at injection site, transient diarrhea, and abnormal bleeding) were mild and self-limiting. In post approval experience, death has been reported in some cases; vomiting, anorexia, depression/ lethargy and diarrhea have also been reported.
For additional safety information, please see the Full Prescribing Information.
Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
If you notice anything unusual, please consult your veterinarian.
Precautions
*For complete product information including warnings and precautions, please refer to the Full Prescribing Information in the manufacturer’s package insert.
For intramuscular use in dogs only—not for use in humans. Keep this and all medications out of reach of children.
PSGAG is a synthetic heparinoid; do not use in dogs with known or suspected bleeding disorders.
Do not use in dogs showing a hypersensitivity to polysulfated glycosaminoglycan.
Use with caution in dogs with renal or hepatic impairment.
The use of Adequan® Canine in breeding, pregnant, or lactating dogs has not been evaluated.
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
For additional safety information, please see the Full Prescribing Information.
Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.
Drug and food interactions
American Regent Animal Health has not conducted any studies evaluating the combined use of specific drugs or supplements. Before starting any treatment, advise your veterinarian of any medications, supplements or natural products your dog is currently taking. Do not mix Adequan Canine with other drugs or solvents.
Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer American Regent Animal Health at 1-888-354-4857 or Vetsource Pet Owner Care at 877-738-4443.
Overdose
If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.
For humans:
The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.
For animals:
The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.
*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.
Disclaimer
The content provided on this page is NOT medical advice.
All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.
Last revised: 12/11/2025
-
Description
Product detailsAdequan® Canine is recommended for intramuscular injection for the control of signs associated with non-infectious degenerative and/or traumatic arthritis of canine synovial joints. This is more commonly known as osteoarthritis (OA).- Adequan® Canine (polysulfated glycosaminoglycan) is the only FDA-approved disease-modifying osteoarthritis drug for dogs.
- It proactively treats the disease and not just the signs.
- Adequan® Canine helps to restore joint lubrication, relieve inflammation, and renew the building blocks of healthy joint cartilage - to help keep dogs moving.
- Adequan® Canine can be used early, at the first clinical signs of degenerative joint disease (DJD).
- Continue to use it as prescribed by your veterinarian to treat arthritis and help maintain mobility and comfort.
Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.ForDogsActive ingredient(s)Polysulfated glycosaminoglycan (PSGAG)Inactive ingredientsBenzyl alcohol (preservative), water for injection. May contain sodium hydroxide and/or hydrochloric acid if necessary to adjust pH.Brand nameAdequan CanineDrug classDisease-modifying osteoarthritis drug (DMOAD)ManufacturerAmerican Regent Animal HealthProduct strength & sizeThis sterile injectable solution contains 100 mg of polysulfated glycosaminoglycan per 1 mL of solution and is supplied in 5 mL preserved multiple dose vials. Please ensure the selected product and package size are appropriate for your pet, as recommended by your veterinarian.For current availability, please refer to the product selection above.Usage*For complete product information, please review the Full Prescribing Information in the manufacturer’s package insert.Adequan Canine should be administered as directed by your veterinarian. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.Manufacturer’s Recommended Dosage and Administration:The recommended dose of Adequan Canine is 2 mg/lb. body weight (0.02 mL/lb., or 1mL per 50lb), by intramuscular injection only, twice weekly for up to 4 weeks (maximum of 8 injections).Please consult with your veterinarian and follow all treatments as prescribed. Federal law restricts this drug to use by or on the order of a licensed veterinarian.Injectable medications require needles, syringes, and a designated sharps disposal container. These are not included with the medication and must be purchased separately.Please consult your veterinarian for guidance regarding appropriate needle and syringe sizes for your pet.For general injectable use (aseptic technique):Aseptic technique refers to a set of practices designed to minimize the risk of contamination and infection during medical procedures. These practices can also be applied to the handling and administration of injectable medications to your pet to help reduce the risk of post-injection bacterial infections.Wash your hands thoroughly with soap and water before and after administration.Use a new, sterile needle and syringe for each injection. Needles and syringes should never be reused.Do not touch the needle, syringe tip, or vial stopper (once it has been wiped with alcohol) to any surface to avoid contamination.Adequately clean and disinfect the vial stopper with an alcohol wipe, then allow it to dry before inserting the sterile needle/syringe.Withdraw and administer the prescribed dose as directed by your veterinarian.Dispose of the needle/syringe into a proper sharps disposal container immediately after use.Missed dosesIf a dose is missed: Please consult your veterinarian.If you have questions about your pet’s prescribed dosing schedule (e.g., timing, interval), please consult your veterinarian.StorageAdequan® Canine does not need to be refrigerated.Store at 68° to 77°F, excursions permitted to 59° to 86°F. Avoid prolonged exposure to temperatures ≥ 104°F. Use vial within 28 days of first puncture and puncture a maximum of 10 times.Keep in a secure location out of the reach of children and pets. Exposure to extreme temperatures or moisture may affect the integrity and effectiveness of medications. Always store medications properly (e.g., away from the bathroom, kitchen sink, or other damp places).Side effectsSide effects in clinical studies (transient pain at injection site, transient diarrhea, and abnormal bleeding) were mild and self-limiting. In post approval experience, death has been reported in some cases; vomiting, anorexia, depression/ lethargy and diarrhea have also been reported.For additional safety information, please see the Full Prescribing Information.Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.If you notice anything unusual, please consult your veterinarian.Precautions*For complete product information including warnings and precautions, please refer to the Full Prescribing Information in the manufacturer’s package insert.For intramuscular use in dogs only—not for use in humans. Keep this and all medications out of reach of children.PSGAG is a synthetic heparinoid; do not use in dogs with known or suspected bleeding disorders.Do not use in dogs showing a hypersensitivity to polysulfated glycosaminoglycan.Use with caution in dogs with renal or hepatic impairment.The use of Adequan® Canine in breeding, pregnant, or lactating dogs has not been evaluated.Federal law restricts this drug to use by or on the order of a licensed veterinarian.For additional safety information, please see the Full Prescribing Information.Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.Drug and food interactionsAmerican Regent Animal Health has not conducted any studies evaluating the combined use of specific drugs or supplements. Before starting any treatment, advise your veterinarian of any medications, supplements or natural products your dog is currently taking. Do not mix Adequan Canine with other drugs or solvents.Adverse reactionsIf you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer American Regent Animal Health at 1-888-354-4857 or Vetsource Pet Owner Care at 877-738-4443.OverdoseIf you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.For humans:The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.For animals:The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.DisclaimerThe content provided on this page is NOT medical advice.All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.Last revised: 12/11/2025 -
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