Product details
Zenrelia (ilunocitinib tablets) is indicated for control of pruritus (itching) associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
This product is an oral tablet formulation.
- Zenrelia relieves itching in dogs due to allergic dermatitis and controls atopic dermatitis.
- Zenrelia can get your dog back to normal**, with visible signs of itch relief on day 1*.
- Ilunocitinib, the active ingredient in Zenrelia, works by reducing the itch and inflammatory response in your dog's skin due to allergies.
- The most common side effects reported with this dog dermatitis treatment were vomiting, diarrhea and tiredness; please see product insert for more information.
- The once-daily tablet can be given with or without food from the comfort of your home.
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Warning: Inadequate immune response to vaccines
Based on results of the vaccine response study, dogs receiving Zenrelia are at risk of an inadequate immune response to vaccines. Discontinue Zenrelia for at least 28 days to 3 months prior to vaccination and withhold Zenrelia for at least 28 days after vaccination. See Warnings and Target Animal Safety in the manufacturer product insert for detailed information.
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Allergic dermatitis can make your dog very uncomfortable. Symptoms like excessive itching, scratching, and biting aren't only disruptive to you and your pet, but they can also cause more severe problems over time, including hair loss and skin infection.
Zenrelia is a once-daily tablet that relieves itching due to allergic dermatitis and controls atopic dermatitis.
How it works: The active ingredient, ilunocitinib, reduces the inflammatory response in your dog's skin caused by allergies, making your dog feel less itchy. In fact, dogs may have visible signs of itch relief on day 1*. What's more, Zenrelia is designed to deliver continuous efficacy over the long term and can get your dog back to normal**.
Zenrelia is given once a day with or without food, so it may be easier to incorporate into your daily routine. Always follow your veterinarian's instructions.
The most common side effects reported with this dog dermatitis treatment were vomiting, diarrhea and tiredness; please see product insert for more information.
Zenrelia is a prescription itch relief medication for dogs at least 12 months of age. Ask your veterinarian if Zenrelia can relieve itching in your dog due to allergic and atopic dermatitis.
Fast relief for your best friend is also a relief for you. Spend more time doing the things you love, like cuddling and playing, and less time managing your dog's allergy symptoms.
References:
*Data on file (Elanco Animal Health)
**Clinical remission of itch demonstrated by a Normal-PVAS<2
Please note: The images provided are for illustrative purposes. Your product may be delivered in a Vetsource Pharmacy vial; product packaging & appearance may vary and are subject to manufacturer availability.
Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.
For
Dogs (at least 12 months of age and weighing 6.6 lbs and over)
Active ingredient(s)
Ilunocitinib
Inactive ingredients
Complete inactive ingredients list not provided by manufacturer.
Brand name
Zenrelia
Drug class
Janus kinase (JAK) inhibitor, Immunomodulator
Product flavoring
Zenrelia tablets are not flavored.
*According to the manufacturer, Zenrelia does not contain pork, beef, soy, lactose, or dairy.
Manufacturer
Elanco
Product strength & size
Zenrelia tablets may be available in multiple strengths and/or sizes. Please ensure the selected product and package size are appropriate for your pet, as recommended by your veterinarian.
For current availability, please refer to the product selection above.
Usage
*For complete product information, please review the full prescribing information in the manufacturer package insert.
Zenrelia should be given orally once daily, as prescribed by your veterinarian. Wash your hands thoroughly with soap and water immediately after handling the medication.
Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule. Contact your veterinarian if your pet’s condition worsens or does not improve after starting the medication.
Zenrelia can be administered with or without food. If your pet vomits or appears unwell after receiving a dose on an empty stomach, give future doses with food or a small treat. If vomiting continues, contact your veterinarian.
Missed doses
Administer the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give more medication than prescribed or two doses at once.
If you have questions about your pet’s prescribed dosing schedule (e.g., timing, interval), please consult your veterinarian.
Storage
Store in a cool, dry place at a controlled room temperature (59-77°F), excursions permitted between 41 and 104°F. Keep in a secure location out of the reach of children and pets. Protect from light and moisture.
Exposure to extreme temperatures or moisture may affect the integrity and effectiveness of medications. Always store medications properly (e.g., away from the bathroom, kitchen sink, or other damp places).
Side effects
The most common side effects reported with this medication are vomiting, diarrhea, and lethargy (tiredness).
Contact your veterinarian immediately if you notice signs of an infection (e.g., coughing/wheezing, bleeding or oozing skin sores, painful/frequent urination, etc.), any new and abnormal skin changes/growths, or enlargement of existing skin masses.
This is not a complete list of possible side effects; please refer to the manufacturer’s product insert for more information. Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.
If you notice anything unusual, please consult your veterinarian.
Precautions
*For complete product information including warnings and precautions, please refer to the manufacturer package insert. Read the entire package insert, including the Boxed Warning, before using this drug.
For oral use in dogs only—not for use in humans.
Zenrelia is not for use in dogs less than 12 months of age.
Due to the risk of infections, dogs should be up to date on vaccinations prior to starting Zenrelia. (see Boxed Warning).
Do NOT use Zenrelia in dogs with serious infections.
Consider the risks and benefits of treatment prior to initiating Zenrelia in dogs with a history of recurrent serious infections or recurrent demodicosis or neoplasia.
Wash your hands immediately after handling this medication. In case of accidental eye contact, flush immediately with water or saline for at least 15 minutes, then seek medical attention. In case of accidental ingestion, seek medical attention immediately.
The safe use of Zenrelia has not been evaluated in breeding, pregnant, or lactating dogs. Discuss the risks of using this medication with your veterinarian prior to use if your pet is in one of these groups.
Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.
Drug and food interactions
The following drugs* may have potential interactions with this medication:
cyclosporine, glucocorticoids (e.g., dexamethasone, prednisone), and other systemic immunosuppressive agents (e.g., mycophenolate).
*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.
Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Elanco US at 1-888-545-5973 or Vetsource Pet Owner Care at 877-738-4443.
Overdose
If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.
For humans:
The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.
For animals:
The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.
*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.
Disclaimer
The content provided on this page is NOT medical advice.
All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.
Last revised: 12/03/2025
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Description
Product detailsZenrelia (ilunocitinib tablets) is indicated for control of pruritus (itching) associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. This product is an oral tablet formulation.- Zenrelia relieves itching in dogs due to allergic dermatitis and controls atopic dermatitis.
- Zenrelia can get your dog back to normal**, with visible signs of itch relief on day 1*.
- Ilunocitinib, the active ingredient in Zenrelia, works by reducing the itch and inflammatory response in your dog's skin due to allergies.
- The most common side effects reported with this dog dermatitis treatment were vomiting, diarrhea and tiredness; please see product insert for more information.
- The once-daily tablet can be given with or without food from the comfort of your home.
Warning: Inadequate immune response to vaccines Based on results of the vaccine response study, dogs receiving Zenrelia are at risk of an inadequate immune response to vaccines. Discontinue Zenrelia for at least 28 days to 3 months prior to vaccination and withhold Zenrelia for at least 28 days after vaccination. See Warnings and Target Animal Safety in the manufacturer product insert for detailed information.Allergic dermatitis can make your dog very uncomfortable. Symptoms like excessive itching, scratching, and biting aren't only disruptive to you and your pet, but they can also cause more severe problems over time, including hair loss and skin infection.Zenrelia is a once-daily tablet that relieves itching due to allergic dermatitis and controls atopic dermatitis.How it works: The active ingredient, ilunocitinib, reduces the inflammatory response in your dog's skin caused by allergies, making your dog feel less itchy. In fact, dogs may have visible signs of itch relief on day 1*. What's more, Zenrelia is designed to deliver continuous efficacy over the long term and can get your dog back to normal**.Zenrelia is given once a day with or without food, so it may be easier to incorporate into your daily routine. Always follow your veterinarian's instructions.The most common side effects reported with this dog dermatitis treatment were vomiting, diarrhea and tiredness; please see product insert for more information.Zenrelia is a prescription itch relief medication for dogs at least 12 months of age. Ask your veterinarian if Zenrelia can relieve itching in your dog due to allergic and atopic dermatitis.Fast relief for your best friend is also a relief for you. Spend more time doing the things you love, like cuddling and playing, and less time managing your dog's allergy symptoms.References:*Data on file (Elanco Animal Health)**Clinical remission of itch demonstrated by a Normal-PVAS<2Please note: The images provided are for illustrative purposes. Your product may be delivered in a Vetsource Pharmacy vial; product packaging & appearance may vary and are subject to manufacturer availability.Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.ForDogs (at least 12 months of age and weighing 6.6 lbs and over)Active ingredient(s)IlunocitinibInactive ingredientsComplete inactive ingredients list not provided by manufacturer.Brand nameZenreliaDrug classJanus kinase (JAK) inhibitor, ImmunomodulatorProduct flavoringZenrelia tablets are not flavored.*According to the manufacturer, Zenrelia does not contain pork, beef, soy, lactose, or dairy.ManufacturerElancoProduct strength & sizeZenrelia tablets may be available in multiple strengths and/or sizes. Please ensure the selected product and package size are appropriate for your pet, as recommended by your veterinarian.For current availability, please refer to the product selection above.Usage*For complete product information, please review the full prescribing information in the manufacturer package insert.Zenrelia should be given orally once daily, as prescribed by your veterinarian. Wash your hands thoroughly with soap and water immediately after handling the medication.Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule. Contact your veterinarian if your pet’s condition worsens or does not improve after starting the medication.Zenrelia can be administered with or without food. If your pet vomits or appears unwell after receiving a dose on an empty stomach, give future doses with food or a small treat. If vomiting continues, contact your veterinarian.Missed dosesAdminister the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give more medication than prescribed or two doses at once.If you have questions about your pet’s prescribed dosing schedule (e.g., timing, interval), please consult your veterinarian.StorageStore in a cool, dry place at a controlled room temperature (59-77°F), excursions permitted between 41 and 104°F. Keep in a secure location out of the reach of children and pets. Protect from light and moisture.Exposure to extreme temperatures or moisture may affect the integrity and effectiveness of medications. Always store medications properly (e.g., away from the bathroom, kitchen sink, or other damp places).Side effectsThe most common side effects reported with this medication are vomiting, diarrhea, and lethargy (tiredness).Contact your veterinarian immediately if you notice signs of an infection (e.g., coughing/wheezing, bleeding or oozing skin sores, painful/frequent urination, etc.), any new and abnormal skin changes/growths, or enlargement of existing skin masses.This is not a complete list of possible side effects; please refer to the manufacturer’s product insert for more information. Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.If you notice anything unusual, please consult your veterinarian.Precautions*For complete product information including warnings and precautions, please refer to the manufacturer package insert. Read the entire package insert, including the Boxed Warning, before using this drug.For oral use in dogs only—not for use in humans.Zenrelia is not for use in dogs less than 12 months of age.Due to the risk of infections, dogs should be up to date on vaccinations prior to starting Zenrelia. (see Boxed Warning).Do NOT use Zenrelia in dogs with serious infections.Consider the risks and benefits of treatment prior to initiating Zenrelia in dogs with a history of recurrent serious infections or recurrent demodicosis or neoplasia.Wash your hands immediately after handling this medication. In case of accidental eye contact, flush immediately with water or saline for at least 15 minutes, then seek medical attention. In case of accidental ingestion, seek medical attention immediately.The safe use of Zenrelia has not been evaluated in breeding, pregnant, or lactating dogs. Discuss the risks of using this medication with your veterinarian prior to use if your pet is in one of these groups.Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.Drug and food interactionsThe following drugs* may have potential interactions with this medication: cyclosporine, glucocorticoids (e.g., dexamethasone, prednisone), and other systemic immunosuppressive agents (e.g., mycophenolate).*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.Adverse reactionsIf you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Elanco US at 1-888-545-5973 or Vetsource Pet Owner Care at 877-738-4443.OverdoseIf you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.For humans:The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.For animals:The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.DisclaimerThe content provided on this page is NOT medical advice.All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.Last revised: 12/03/2025 -
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