Zycosan Injectable Solution

A Chemical on the Prop 65 List

Zycosan® (pentosan polysulfate sodium injection)

Zycosan® is indicated for the control of clinical signs associated with osteoarthritis in horses.

Horses

Pentosan Polysulfate 

Zycosan® Injection

Anti-inflammatory, Osteoarthritis Disease-Modifier

Dechra

Zycosan® 250 mg/ml Injection 7.5 ml Vial (4 Count): Pale yellow to brownish yellow, clear, sterile solution. (NDC 17033-0461-75)

Pentosan polysulfate sodium

Zycosan® should be administered as directed by your veterinarian.  May cause skin irritation.  Wear gloves and wash hands thoroughly after administration. Use aseptic techniques when withdrawing each dose to decrease the possibility of post-injection bacterial infections. Adequately clean and disinfect the stopper prior to entry with a sterile needle and syringe. Injectable medications require needles and syringes.  Those items are purchased separately.  Please ask your veterinarian for a recommendation for the correct needle/syringe sizes for your pet. Use only sterile needles/syringes and use each needle/syringe only once. Dispose the needle/syringe immediately in a proper sharps disposal container. Sharps containers are sold separately.

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give 2 doses at once.

Side effects are not expected to occur with normal doses. Injection site reactions may occur. If you notice anything unusual, contact your veterinarian.

Use caution when combining with other medications that may interfere with blood clotting, NSAIDS or other anticoagulants, dexamethasone, prednisone, prednisolone, or triamcinolone. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.  

Make sure to tell your veterinarian what other medication you are giving to your pet.  Quite often your veterinarian may prescribe two different medications, even if a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely. 

Not for use in humans. Zycosan® has been shown to prolong coagulation parameters up to 24 hours after injection, therefore caution should be used when administering this drug before or after strenuous activities. Due to the anticoagulant effects, this drug may exacerbate Exercise Induced Pulmonary Hemorrhage (EIPH).

The concurrent use of NSAIDs with Zycosan® has not been evaluated. Due to the anticoagulant effects of Zycosan® and known anticoagulant effects of some NSAIDs, caution should be used if NSAIDs are concurrently administered. Horses concurrently treated with Zycosan® and NSAIDs should be monitored for hemorrhage or other clinical signs of abnormal bleeding (e.g., petechiae, ecchymosis, or epistaxis).

Pentosan polysulfate sodium is a weak anticoagulant. Caution should be used when administering Zycosan® if you are taking an anticoagulant. In case of accidental self-injection, seek immediate medical attention. If product comes into contact with skin, rinse skin thoroughly with water and seek medical attention if needed. 

Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; widespread hives and itching.

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Dechra at 866-933-2472 or Vetsource customer service at 877-738-4443.

Store at 68°F to 77°F in controlled room temperature, excursion permitted between 59°F to 86°F. Do not freeze. Keep this medicine out of reach of children. Store in a childproof container. Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight. Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.